Dr Pramila Krishnamurthy, King’s College Hospital and King’s College London and Leukaemia UK John Goldman Fellow

Dr Krishnamurthy will be using the fellowship to better understand why some leukaemia patients relapse following a stem cell transplant, and how donor lymphocyte infusion can help prevent this.

Stem cell transplantation is a life-saving treatment which is often the only effective treatment for acute myeloid leukaemia (AML), the most common type of acute leukaemia in adults. Yet the relapse rates following stem cell transplants are high and AML is one of the most deadly forms of blood cancer. 

Dr Krishnamurthy will explore the effectiveness of a donor lymphocyte infusion (DLI) and how this may correct a patient’s immune response to help eliminate remaining leukaemic cells and prevent relapse. 

“Over 50% of patients with acute leukaemias relapse after stem cell transplant, and once this occurs, the chance of cure is unlikely. Relapse can be prevented by infusing donor-derived immune cells after the transplant. During my John Goldman Fellowship I will explore the use of donor lymphocyte infusion to help correct defects in patients’ immune responses so that they are better able to fight their underlying cancer.”

This John Goldman Fellowship is co-funded by Rosetrees Trust, a charitable family foundation with a substantial track-record of funding vital medical research for over thirty years.

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With blood cancer being the third biggest cancer killer in the UK, we strive to find better treatments and care to make a difference to those affected by leukaemia and other blood cancers.

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