AML: What is the role of the GATA2 protein? The GATA2 protein helps regulate blood cell development and has two main functions: it binds DNA to switch genes on or off, and can simultaneously associate with other proteins to regulate genes. If either of these functions are disrupted, it can alter the development of blood cells in the body. Many mutations of the GATA2 protein have been identified, but it is still not known how these errors cause leukaemia. Dr Nurmohamed's work aims to decipher the mechanism of the GATA2 protein in normal blood development and explain how these GATA2 mutations cause acute myeloid leukaemia (AML). From the results of this research, we hope to progress the design and development of new and improved treatments.